GS070092   Molecular Basis of Microbial Pathogenesis

Garsin, Danielle. Two semester hours. Spring annually. Prerequisites: Microbiology and Molecular Genetics I (GS070014) and Microbiology and Molecular Genetics II (GS040024), or consent of instructor.

An advanced level course covering current areas of interest in microbial pathogenesis. The goal of the course is to provide a comprehensive overview of the molecular basis of pathogenesis through a critical evaluation of recent scientific papers and reviews. Students, with faculty guidance, will also develop an original grant proposal on a subject of their choosing in microbial pathogenesis. Topics for discussion will include: host-pathogen signal exchange, environmental control of gene expression, genotypic rearrangements associated with pathogenesis, toxin structure and function, bacterial attachment to host cells, invasion of host cells, intracellular growth, and cell-to-cell spread.