Bharat B. Aggarwal, Ph.D.
1977, University of California, Berkeley
UT M. D. Anderson Cancer Center
Experimental Therapeutics
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Bharat B. Aggarwal, Ph.D. 1977, University of California, Berkeley UT M. D. Anderson Cancer Center |
Research Interests: Cytokines; lymphokines; monokines; tumor necrosis factors; purification; cDNA cloning; mechanism of action; growth inhibitors and stimulators; tumor cell resistance; receptors; signal transduction
The long-range objective of our research is to identify various tumor cell growth regulatory factors produced by the cells of the immune system and also by tumor cells which may have a role in cancer. We will purify, determine the amino acid sequence and clone the cDNA of these cytokines. We will also examine the mechanism of their action on various tumors in vitro and in vivo. The role of oncogenes, growth factors, and signal transduction in tumor cell resistance is also an important focus of our laboratory.
A tutorial in our laboratory will provide experience in protein purification, molecular biology, cell culture, bioassays, and radioreceptor assays.
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Shishodia S, Aggarwal BB (2002) Nuclear factor-kB activation: A question of life and death. J Biochem Molec Biol 35:28-40.
Bharti AC, Aggarwal BB (2002) Nuclear factor-kB and cancer: Its role in prevention and therapy. Biochem Pharmacol (in press)
Garg A, Aggarwal BB (2002) Nuclear transcription factor-kB as a target for cancer drug development. Leukemia (in press)
Majumdar S, Lamothe B, Aggarwal BB (2002) Thalidomide suppresses nuclear factor-kB activation induced by TNF and H2O2 but not that induced by ceramide, lipopolysaccharides or phorbol ester. J Immunol 168:2644-2651.
Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, Pantazis P, Aggarwal BB (2001) Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20:7597-7609.
Mukhopadhyay A, Suttles J, Stout RD, Aggarwal BB (2001) Genetic deletion of the tumor necrosis factor receptor -p60 or p80 abrogates ligand-mediated activation of nuclear factor-kB and of mitogen activated protein kinases in macrophages. J Biol Chem 276(34):31906-12.
Majumdar S, Aggarwal BB (2001) Methotrexate suppresses nuclear factor-kB activation through inhibition of IkBa phosphorylation and degradation. J Immunol 167:2911-2920.
Program Affiliation:
Program in Immunology