Constance T. Albarracin, M.D., Ph.D.
1985, University of Santo Tomas, Philippines
1993, University of Illinois at Chicago
UT M. D. Anderson Cancer Center
Pathology
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Constance T. Albarracin, M.D., Ph.D. 1985, University of Santo Tomas, Philippines UT M. D. Anderson Cancer Center |
Research Interests: hormone regulated proteins; development of breast , endometrial and esophageal cancer; annexin 1; annexin 2; 17-Beta hydroxysteroid dehydrogenase; microRNAs and cancers
Our goal is to characterize the role of hormone regulated proteins in the development of breast cancer and their aggressive behavior (higher stage, metastasis, recurrence, resistance to therapy). In particular, our goal is to determine the role and regulation of the calcium binding protein, annexin 1, in breast and esophageal cancers. This will involve the use of tissue microarrays to analyze protein expression in tumors and subsequent correlation with histopathologic features and clinical parameters. The mechanism of action of annexin 1 will be studied in several breast cancer cell lines. In addition, stable breast cell lines with annexin 1 overexpression and annexin 1 knockdown have been developed in our laboratory and are currently being characterized using mRNA and microRNA profiling.
A tutorial in my laboratory will depend on the student's interests, experience, and duration of stay in the laboratory. Current projects can provide experience in tissue microarray, immunohistochemical techniques, digital imaging analysis, tissue culture, protein preparation, immunoprecipitation, gel electrophoresis, signal transduction mechanisms.
Program Affiliation:
Molecular Pathology