Kenneth Aldape, M.D.
1991, University of California-San Francisco
UT M. D. Anderson Cancer Center
Pathology
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Kenneth Aldape, M.D. 1991, University of California-San Francisco UT M. D. Anderson Cancer Center |
Research Interests: Role of oncogenes in behavior of human cancer; primary human brain tumors; molecular genetic aberrations in cancer; molecular marker studies
Research in my laboratory is focused on the characterization of molecular genetic aberrations in human brain tumors. Techniques include genome-wide views of DNA, RNA and protein changes relevant to the clinical behavior of these neoplasms. Tumor tissue is used to identify aberrations and model systems are used to characterize functional consequences of these aberrations.
My laboratory would provide a student with exposure to the use of tumor specimens for molecular marker studies, including experience in histopathology and immunohistochemistry. Molecular genetic techniques, including PCR, real-time PCR cloning would be used, as well as tissue culture and gene transfection.
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Zhang L, Miles M, Aldape K (2003) A model of molecular interactions on short oligonucleotide microarrays: Implications for probe design and data analysis. Nature Biotechnology (in press)
Burton E, Lamborn K, Feuerstein BG, Prados M, Scott J, Forsuth P, Passe S, Jenkins RB, Aldape KD (2002) Genetic aberrations defined by comparative genomic hybridization distinguish long-term from typical survivors of glioblastoma. Cancer Res 62:6205-6210.
Weiss WA, Israel M, Cobbs C, Holland E, James CD, Louis DN, Marks C, McClatchey AI, Roberts T, Van Dyke T, Wetmore C, Chiu IM, Giovannini M, Guha A, Higgins RJ, Marino S, Radovanovic I, Reilly K, Aldape K (2002) Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene 21(49):7453-63.
Nigro J, Takahashi M, Ginzinger D, Law M, Passe S, Jenkins R, Aldape K (2001) Detection of 1p and 19q loss in oligoendroglioma by quantitative microsatellite analysis, a real-time quantitative PCR assay. Am J Pathol 159:1253-62.
Program Affiliation:
Program in Human and Molecular Genetics