Christopher I. Amos, Ph.D.

1988, LSU Medical Center, New Orleans

UT M. D. Anderson Cancer Center
Epidemiology

Research Interests: Mathematical genetics; cancer genetics; genetics of common diseases; genetic risk assessment

I focus on the developing mathematical tools for the study of the genetic etiology of common diseases. I have developed statistical methodology for genetic linkage studies of common diseases. One of my current areas of research extends multivariate techniques for genetic linkage analysis. I also have several grants to apply linkage methods in the study of familial lung cancer, familial rheumatoid arthritis and for linkage analysis in families of quantitative traits such as hypertension. Together with other members of the Department of Epidemiology at the UT MDACC we have developed several software programs for the analysis of family data and for database management. The Department of Epidemiology has laboratory and office space for student research, extensive computational support including six Sun workstation processors which support programs for genetic analysis including PAP, LINKAGE, and SAGE, as well as standard programming and database management languages.

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Amos CI, Zhu DK, Boerwinke E (1996) Assessing genetic linkage with robust components of variance approaches. Ann Hum Genet 60:143-160.

Amos CI, Wan Y, Siminovitch KA, Rubin LA (1997) Estimating the strength of genetic effects: A comparison of maximum likelihood and transmission disequilibrium methods in the study of Ankylosing Spondylitis. Hum Immun 57:44-50.

Amos CI, Rubin LA (1995) Major gene analysis for diseases and disorders of complex etiology. Exp Clin Immunogenet 12:141-155.

Program Affiliation:
Program in Biomathematics and Biostatistics
Program in Human and Molecular Genetics