Honnavara N. Ananthaswamy, Ph.D.

1975, University of Missouri-Columbia

UT M. D. Anderson Cancer Center
Immunology

Research Interests: Skin cancer; oncogenes and tumor suppressor genes; apoptosis

The research in my laboratory is aimed at investigating the molecular mechanisms by which UV radiation induces skin cancer. We are using mouse models and mouse and human tumor cell lines to study the role of oncogenes and tumor suppressor genes in carcinogenesis as well as targeting those genes for cancer therapy.

A tutorial in my laboratory would provide experience in PCR and nucleotide sequencing, gel electrophoresis, Southern, Northern and Western Blotting, tissue culture and other molecular techniques.
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Bolshakov S, Walker CM, Strom S, Selvan MS, Clayman G, El-Naggar A, Lippman SM, Kripke ML, Ananthaswamy HN (2003) p53 Mutations in human aggressive and non-aggressive basal and squamous cell carcinomas. Clin Cancer Res, 9: 228-234.

Melnikova V, Santamaria AB, Bolshakov SV, Ananthaswamy HN (2003) Mutant p53 is constitutively phosphorylated at serine 15 in UV-induced mouse skin tumors: Involvement of ERK1/2MAP kinase. Oncogene, 22: 5958-5966.

Melnikova M, Bolshakov S, Walker C, Ananthaswamy HN (2004) Genomic alterations in spontaneous and carcinogen-induced murine melanoma cell lines. Oncogene, 23: 2343-2352.

Agar NS, Halliday GM, Barnetson RStC, Ananthaswamy HN, Wheeler M, Jones AM (2004) Basal keratinocytes in human squamous cell carcinoma and solar keratosis harbour more UVA than UVB fingerprint mutations: Evidence for the role of UVA in human skin carcinogenesis. Proc Natl Acad Sci, 101: 4954-4959.

Melnikova VO, Ananthaswamy HN (2005) Cellular and molecular events leading to the development of skin cancer. Mutation Res, 571: 91-106.

Melnikova VO, Pacifico A, Chimenti S, Peris K, Ananthaswamy HN (2005) Fate of UV-induced p53 mutations in SKH-hr1 mouse skin after discontinuation of irradiation: relationship to skin cancer development. Oncogene, 24: 7055-7063.

Program Affiliations:
Program in Cancer Biology
Program in Immunology