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Joe M. Angel, Ph.D. 1982, The University of Texas Graduate School of Biomedical Sciences at Houston The University of Texas M. D. Anderson Cancer Center My laboratory is located in Smithville, Texas, at UT Science Park -- Research Division. |
Research Interests:
The overall goal of my research is to study the genetics of carcinogenesis
in the mouse. The primary model that I have used is N-methyl-N-nitrosourea (MNU)
induction of thymic lymphomas in AKR mice. Treatment of 6-week-old AKR mice
with a single dose of MNU accelerates tumor inset, with approximately 75% of
male AKR mice developing thymic lymphomas between 4 and 6 months of age. Interestingly,
AKR mice have a higher incidence and shorter latency of MNU-induced tumors than
most other inbred strains that have been examined, suggesting that host genes
determine the sensitivity of mice to MNU induction of tumors. The results of
our studies of MNU-induced lymphomas in genetic crosses of AKR mice with C57L
mice suggested that 2 or more genes, dominant in C57L, determine the susceptibility
of mice to MNU. One of these genes was found to be linked to the albino locus
on mouse chromosome 7. Preliminary analysis using multilocus probes revealed
linkage of a second gene associated with MNU susceptibility to the proximal
region of mouse chromosome 12. Additional mapping studies using polymorphic
simple-sequence repeat markers have verified the linkage of tumor susceptibility
to this region, and more mapping studies are being conducted to map this gene
more precisely. Our future plans are to clone and characterize candidate tumor
susceptibility genes from this region.
Publications
Program Affiliation:
Program in Molecular Carcinogenesis