Ananth Annapragada, Ph.D.
1989, University of Michigan
UT-Houston
School of Health Information Sciences
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Ananth Annapragada, Ph.D. 1989, University of Michigan UT-Houston |
Research Interests: Targeted drug delivery; respiratory drug delivery; computational methods in biomedicine; targeted delivery of contrast agents for various imaging modalities
Research in my laboratory is directed towards new techniques for delivery of drugs and contrast agents to target tissues with a high level of specificity, and a minimization of side effects. We approach this class of problems with a combination of (1) computational simulations to understand the physics and chemistry, (2) synthetic chemistry and nanofabrication to build appropriate agent carriers and devices, (3) in vitro and in vivo testing of the prepared constructs, and (4) constant revision of our quantitative theoretical basis for the original designs. Our achievements include the development of technology to enable patient-specific aerosol delivery protocols, and a new class of blood-pool contrast agents for CT.
Depending on the student's interests, a tutorial in my laboratory would provide experience with computational methods in biomedicine, or chemistry/engineering methods to fabricate new classes of nanoparticle based drug and contrast agent carriers.
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Nowak N, Kakade P, Annapragada A (2003) CFD simulation of airflow and drug deposition in human lungs. Ann. Biomed. Eng. 31:4.
Kao CY, Hoffman E, Beck K, Bellamkonda R, Annapragada A (2003) Novel nanoscale long-circulating liposomal blood pool contrast agent for CT imaging. Academic Radiology. Acad. Radiol. 10(5), 475-483.
E Karathanasis, AL Ayyagari, R Bhavane, RV Bellamkonda, AV Annapragada (2005) Preparation of in vivo cleavable agglomerated liposomes suitable for modulated pulmonary drug delivery, Journal of Controlled Release 103 (1) 159-175.
K Ghaghada, J Saul, R Bellamkonda, A Annapragada (2005) “Folate targeting of drug carriers to tumor sites-A mathematical model”. Journal of Controlled Release 104 113-128.
E Karathanassis, R Bhavane, A Annapragada (2006) Cysteine-Triggered Release of Inhaled Insulin from the Agglomerated Vesicles: Pharmacodynamic Studies in Rats” J Control Release. Jun 28;113(2):117-27. Epub 2006 Apr 25.
S Mukundan, K Ghaghada, C Badea, C Kao, L Hedlund, J Provenzale, G Johnson, E Chen, R Bellamkonda, A Annapragada (2005) “A liposomal nanoscale contrast agent for preclinical CT in mice” American Journal of Radiology 186 300-307.
AL Ayyagari, X Zhang, KB Ghaghada, A Annapragada, XH Ravi, V Bellamkonda (2006) “Long Circulating Liposomal-based Contrast Agents for 3D Magnetic Resonance Imaging” Magn Reson Med. May;55(5):1023-9.
K Ghaghada, S Mukundan, P Narayana, A Annapragada (2007) "High Resolution Vascular Imaging of the Rat Spine using Liposomal Blood Pool MR Agent" AJNR Am J Neuroradiol. Jan;28(1):48-53.
Saul JM, Annapragada AV, Bellamkonda RV. (2006) “A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers.” J Control Release. 2006 Sep 12;114(3):277-87. Epub 2006 Jun 7.
Burke SJ, Annapragada A, Hoffman EA, Chen E, Ghaghada KB, Sieren J, van Beek EJ (2007) “Imaging of Pulmonary Embolism and t-PA Therapy Effects Using MDCT and Liposomal Iohexol Blood Pool Agent Preliminary Results in a Rabbit Model.” Acad Radiol. Mar;14(3):355-62.
R Bhavane, E Karathanassis, A Annapragada (2007)"Triggered Release of Ciprofloxacin from Nanostructured Agglomerated Vesicles" Int. J. Nanomed. Accepted, to be published April.
E Karathanassis, R Bhavane, A Annapragada (2007) “Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats”. Int. J. Nanomed. 2(3) 1-13.
E Karathanasis*, K McNeeley*, A Agarwal*, AV Annapragada**, RV Bellamkonda* (2007) “MR trackable chemotherapeutic nanoparticles for patient specific glioma therapy” Microsc Microanal 13(Suppl 2), 2007.
J Sakamoto, A Annapragada, P Decuzzi, M Ferrari (2007) “Antibiological barrier nanovector technology for cancer applications” Expert Opin. Drug Deliv. 4(4):359-369
K McNeeley, A Annapragada, R Bellamkonda (2007) Folate targeting of Doxorubicin liposomes: in vivo studies. Nanotechnology, In Press.
A Annapragada, N Mishchiy (2007) “In-silico modeling of aerosol deposition in lungs” Current Opinions in Drug Delivery.