Jaroslaw A. Aronowski, Ph.D.
1992, Polish Academy of Sciences
UT-Houston Medical School
Neurology
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Jaroslaw A. Aronowski, Ph.D. 1992, Polish Academy of Sciences UT-Houston Medical School |
Research Interests: Animal models of cerebral ischemia; neuroprotection; protein phosphorylation; transcription factors; inflammation; neuronal death
Our research involves understanding the cellular and molecular mechanisms underlying the pathology of acute cerebral ischemia and intracerebral hemorrhage, with emphasis on calcium related signal transduction, protein phosphorylation, transcription factors, apoptosis, and inflammatory response. Utilizing behavioral animal models, we are also investigating the effect of motor and cognitive activities on neuronal plasticity and delayed recovery from stroke. Using relevant animal models, including transgenic mice, we are evaluating new clinically relevant experimental pharmacotherapies with different mechanisms of action targeting the acute and recovery phase of stroke and ICH pathology.
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Aronowski J, Hall C (2005) New horizons for primary intracerebral hemorrhage treatment: Experience from preclinical studies. Neurol Res 27:268-279.
Zhao X, Aronowski J, Liu S-J, Schallert T, Zhang J, Strong R, Ou Z, Nguyen T, Grotta JC (2005) Wheel-Running Modestly Promotes Functional Recovery After a Unilateral Cortical Lesion in Rats. Behavioral Neurology 16:41-49.
Zhao, X, Aronowski J, Sun G, Zhang J, Strong R, Zhang Y, Nguyen T, Grotta JC (2005) Edaravone and Caffeinol Are Neuroprotective After Transient Middle Cerebral Artery Occlusio in Rats. J Neurol Sci 22, 374-381.
Schneider A, Krueger c, Steigleder T, Weber D, Pitzer C, Laage R, Aronowski J, Maurer MH, Gassler N, Mier W, Hasselblatt M, Kollmar R, Schwab S, Sommer C, Bach A, Kuhn H-G, Schabitz W-R (2005) The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 115, 2083-2098.
Zhao X, Zhang Y, Strong R, Grotta JC, Aronowski J (2006) 15d-prostaglandin J2 activates peroxisome proliferator activated receptor-gamma, promotes expression of catalase and reduced inflammation, behavioral dysfunction and neuronal loss after intracerebral hemorrhage in rats. J Cereb Blood Flow Metab, 26:811-20.
Zhao J, Kobori N, Aronowski J, Dash PK (2006) Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 393, 108-112.
Zhao X, Ou Z, Grotta JC, Waxham NM, Aronowski J (2006) Peroxisome proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity. Brain Res 1073-1074:460-9.
Ou Z, Zhao X, Grotta JC, Labiche LA, Strong R, Hermann O, Aronowski J (2006) Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-Prostaglandin J2-mediated protection of brain after experimental cerebral ischemia in rat. Brain Res 1096, 196-203.
Kelly KM, Jukkola PI, Kharlamov EA, Downey KL, Strong R, Aronowski J (2006) Long-Term Video-EEG Recordings Following Transient Unilateral Middle Cerebral and Common Carotid Artery Occlusion in Long-Evans Rats. Exp Neurol 201(2):495-506.
Victor NA, Wanderi EW, Gamboa J, Zhao X, Aronowski J, Deininger K, Lust WD, Landreth GE, Sundararajan S (2006) Altered PPARgamma expression and activation after transient focal ischemia in rats. Eur J Neurosci 24, 1653-1663.
Zhao X, Zhang Y, Strong R, Zhang J, Grotta JC, Aronowski J (2007) Distinct patterns of intracerebral hemorrhage-induced alterations in NF-□B subunit, iNOS and COX-2 expression. J Neurochem 101(3):652-63.
Zhao X, Sun G, Strong R, Song W, Gonzalez N, Grotta JC, Aronowski J (2007) Hematoma resolution as a target for intracerebral hemorrhage treatment: Role for PPARgamma in microglia/macrophage. Annals of Neurology 61(4):352-362.
Du M, Ulrich H, Zhao X, Aronowski J, Jayaraman V (2007) Water soluble RNA based antagonist of AMPA receptors. Neuropharmacology 53(2):242-51, 2007.
Schabitz WR, Kruger c, Pitzer C, Weber D, Laage R, Gassler N, Aronowski J, Mier W, Kirsch F, Diggten T, Bach A, Sommer C, Schneider A. A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF). J Cereb Blood Flow Metab (in press).
Hallevi H, Albright KC, Aronowski J, Barreto A, Martin-Schild S, Khaja A, Gonzalez N, Illoh K, Noser E, Grotta JC. Intraventricular Hemorrhage: Anatomic Relationships and Clinical Implications. Neurology (in press).
Zhao X, Sun G, Zhang J, Strong R, Dash PK, Kan Y-W, Grotta JC, Aronowski J (2007) The transcription factor Nrf2 protects brain from damage produced by intracerebral hemorrhage. Stroke 38(12):3280-6.
Hallevi H, Aronowski J (2007) The life after SAINT. Int J Stroke 2(4):241-242.
Program Affiliation:
Program in Neuroscience