Menashe Bar-Eli, Ph.D.
1978, Hebrew University
UT M. D. Anderson Cancer Center
Cancer Biology
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Menashe Bar-Eli, Ph.D. 1978, Hebrew University UT M. D. Anderson Cancer Center |
Research Interests: Tumor suppressor genes; melanoma; transcriptional factors; molecular mechanisms of metastatic processes
The main objective of my research is to investigate the molecular events that are associated with the progression of human melanoma from radial growth phase to the vertical growth phase (metastatic phenotype) with the emphasis in developing therapeutic means to block metastases formation. Recently we have identified the transcription factors AP-2 and CREB/ATF-1 as an important regulators of several genes involved in the progression of human melanoma.
A tutorial in my laboratory would provide experience in basic and advanced molecular biology in gene expression and regulation of tumor metastasis.
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Huang S, Jean D, Luca M, Tainsky M, Bar-Eli, M (1998) Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. EMBO J 17:4358-4369.
Jean D, Harbison M, McConkey DJ, Ronai Z, Bar-Eli M (1998) CREB and its associated-proteins act as survival factors for human melanoma cells. J Biol Chem 273:24884-24890.
Jean D, Gershenwald JE, Huang S, Luca M, Hudson MJ, Tainsky AM, Bar-Eli M (1998) Loss of AP-2 results in upregulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells. J Biol Chem 273:16501-16508.
Nyormoi O, Wang Z, Doan D, Ruiz M, McConkey DJ, Bar-Eli M (2001) Transcription factor AP-2 is cleaved and inactivated by caspase-6 during TNF-induced apoptosis. Mol Cell Biol (MCB) 21:4856-4867.
Huang S, Mills L, Mian B, Tellez C, McCarty M, Yang X-D, Gudes JM, Bar-Eli M (2002) Fully humanized neutralizing antibodies to IL-8 (ABX-IL8) inhibit angiogenesis, tumor growth and metastasis of human melanoma. Am J Pathol (in press)
Program Affiliation:
Program in Cancer Biology