Andrew J. Bean, Ph.D.
1990, Yale University
UT-Houston Medical School
Neurobiology and Anatomy
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Andrew J. Bean, Ph.D. 1990, Yale University UT-Houston Medical School |
Research Interests: Mechanisms of vesicular trafficking including neurotransmitter secretion, endocytosis, and protein sorting.
The research in my laboratory is directed at understanding molecular mechanisms of vesicular trafficking and protein sorting. This fundamental process underlies synaptic transmission, which is critical for all brain processes and contributes to functions as basic as the development of neuronal architecture and learning/memory formation. Additionally, the mechanisms responsible for vesicular trafficking are also involved in viral (e.g. HIV) budding, and some types of cancer underscoring the essential nature of this process.
A tutorial in my laboratory would provide experience with biochemical/molecular
biological techniques including cloning/mutagenesis and protein purification
as well as cell biological techniques using cell-free and in situ assays.
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Bean, A.J., Davanger, S., Chou, M.F., Gerhardt, B., Tsujimoto, S., and Chang, Y. Hrs-2 regulates both endocytic and exocytic machinery via calcium-sensitive protein interactions with SNAP-25 and Eps15, J. Biol. Chem. 275:15271-15278, 2000.
Sun, W., Yan, Q., Vida, T.A., and Bean, A.J., Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex. J. Cell Biol. 162:125-137, 2003.
Yan, Q., Sun, W., McNew, J.A., Vida, T.A., Bean, A.J., Ca2+ and N-Ethylmaleimide-sensitive Factor Differentially Regulate Disassembly of SNARE Complexes on Early Endosomes. J. Biol. Chem. 279:18270-18276, 2004.
Yan, Q., Hunt, P. R., Frelin, L., Vida, T.A., Pevsner, J., and Bean A.J. mVPS24 functions in EGF receptor sorting/trafficking from the early endosome. Exp. Cell Res. 304:265-273, 2005.
Yan, Q. Sun W., Kujala, P., Lotfi, Y., Vida, T.A., and Bean, A.J., CART: an Hrs/actinin-4/BERP/myosinV protein complex required for efficient receptor recycling. Mol. Biol. Cell 16:2470-2482, 2005.
Program Affiliation:
Program in Neuroscience