Michael Beierlein, Ph.D.
2000, Brown University
The University of Texas Health Science Center at Houston
Medical School
Department of Neurobiology and Anatomy
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Michael Beierlein, Ph.D. 2000, Brown University The University of Texas Health Science Center at Houston |
Research Interests:
My laboratory uses electrophysiological and optical recording techniques in neocortical brain slices of rodents to explore the mechanisms underlying synaptic plasticity and its importance for local circuit behavior. Ultimately this knowledge will help us to understand the computations performed in neuronal networks that mediate perception, memory formation and higher cognitive functions.
Depending on the student’s interests, a tutorial in my laboratory would provide experience with the preparation of thalamocortical brain slices, electrophysiological recordings from single or synaptically connected neurons, and optical recording techniques using fluorescent indicators.
Selected Publications:
Beierlein M, Fioravante D, Regehr W G (2007) Differential expression of post-tetanic potentiation and retrograde signaling mediate target-dependent short-term synaptic plasticity. Neuron 54(6): 949-959.
Beierlein M, Regehr W G (2006) Local interneurons regulate synaptic strength by retrograde release of endocannabinoids. J Neurosci 26: 9935-9943.
Beierlein M, Regehr W G (2006) Brief bursts of parallel fiber activity trigger calcium waves in Bergmann glia. J Neurosci 26: 6958-6967.
Beierlein M, Gee K R, Martin V V, Regehr W R (2004) Presynaptic calcium measurements at physiological temperatures using a new class of dextran-conjugated indicators. J Neurophysiol 92: 591-599.
Additional Publications
Program Affiliation:
Program in Neuroscience