Russell R. Broaddus, M.D., Ph.D.
1994, UT-Houston Medical School; 1994, The University of Texas-Houston, GSBS
UT M. D. Anderson Cancer Center
Pathology
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Russell R. Broaddus, M.D., Ph.D. 1994, UT-Houston Medical School; 1994, The University of Texas-Houston, GSBS UT M. D. Anderson Cancer Center |
Research Interests: Endometrial cancer; gene methylation; cancer biomarkers; chemoprevention
Our lab is primarily focused on the study of the molecular pathogenesis of endometrial cancer, the most common gynecological cancer in women. Current projects in the lab are examining the molecular differences between aggressive and non-invasive endometrial cancers, gene methylation patterns in endometrial cancer, and the characterization of novel genes important in endometrial cancer.
Our collaborators include David Loose, Ph.D., and Pete Davies, M.D., Ph.D. (Integrative Biology, UT-Houston Medical School), Karen Lu, M.D. (Gynecologic Oncology, MDACC), Cheryl Walker, Ph.D. ( MDACC-Science Park), and Rakesh Kumar, Ph.D. (Molecular & Cellular Oncology, MDACC).
Depending on the interests of the student, a tutorial in this laboratory would provide experience in tissue culture, DNA and RNA extraction from cell lines, paraffin-embedded tissues, and frozen tissues, PCR, Western blotting, and immunohistochemistry.
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Deng, L., Shipley, G.L., Loose-Mitchell, D.S., Stancel, G.M., Broaddus, R.R., Pickar, J.H., Davies, P.J.A. Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium. J Clin Endocrinol Metab 2003; 88: 2157-2163.
Broaddus, R.R., Lynch, P.M., Lu, K.H., Luthra, R., Michelson, S.J. Unusual tumors associated with hereditary non-polyposis colorectal cancer syndrome. Mod Pathol 2004; 17: 981-989.
Slomovitz, B.M., Broaddus, R.R., Burke, T.W., Sneige, N., Soliman, P.T., Wu, W., Sun, C.C., Munsell, M.F., Gershenson, D.M., Lu, K.H. Her-2/neu overexpression and amplification in uterine papillary serous carcinoma. J Clin Oncol 2004; 22: 3126-32.
Lu, K.H., Dinh, M., Kohlmann, W., Watson, P., Green, J., Syngal, S., Bandipalliam, P., Chen, L., Allen, B., Conrad, P., Terdiman, J., Sun, C., Daniels, M., Burke, T., Gershenson, D.M., Lynch, H., Lynch, P., Broaddus, R.R. Gynecologic malignancy as a “sentinel cancer” for women with HNPCC. Obstet Gynecol 2005; 105: 569-574.
Deng, L. Broaddus, R.R., McCampbell, A., Shipley, G.L., Loose, D.S. Stancel, G.M., Pickar, J.H., Davies, P.J.A. (2005) Identification of a novel estrogen regulated gene (EIG121) that is induced by hormone replacement therapy and differentially expressed in type I and type II endometrial cancer. Clin Cancer Res; 11: 8258-8264.
Broaddus, R.R., Lynch, H.T., Chen, L.-m., Daniels, M.S., Conrad, P, Munsell, M.F., White, K.G., Luthra, R., Lu, K.H. (2006) Pathologic features of endometrial cancer associated with HNPCC: a comparison to sporadic endometrial cancer. Cancer; 106: 87-94.
McCampbell, A.S., Broaddus, R.R., Loose, D.S., Davies, P.J.A. (2006) Overexpression of the IGF-I receptor and activation of the AKT pathway in hyperplastic endometrium. Clin Cancer Res; 12: 6373-6378.
Xie, R., Loose, D.S., Shipley, G.L., Xie, S., Bassett, R.L., Broaddus, R.R. (2007) Hypomethylation induced expression of S100A4 in endometrial carcinoma. Mod Pathol; 20: 1045-1054.
Lu, K.H., Schorge, J., Rodabaugh, K., Daniels, M., Sun, C., Soliman, P., White, K., Tran, N., Intengan, M., Luthra, R., Broaddus, R.R. (2007) Prospective determination of prevalence of Lynch Syndrome in young women with endometrial cancer. J Clin Oncol; 25: 5158-5164.
Program Affiliation:
MD/PhD Program