Carlos E. Bueso-Ramos, M.D., Ph.D. 1982, Universidad Autonoma, Tegucigalpa, Honduras 1988, Emory Universitiy School of Medicine UT M. D. Anderson Cancer Center Hematopathology Contact Information Biographical Sketch

Research Interests: Regulation of NFkB activity in hematologic malignancies; gene expression; cell cycle; protein phosphorylation; tumorigenesis; hematopoiesis; molecular genetics of leukemias

The research in my laboratory is directed at understanding transcriptional and post-transcriptional mechanisms regulating gene expression in leukemias. A strong interest in our lab is in factors that affect the regulation of cell lineage determination, maturation arrest, and transformation in leukemia. Current studies in our lab focus on hematopoietic cytokines and DNA binding proteins that regulate the NFkB and p53 pathways.

A tutorial in my laboratory would provide experience with leukemias, morphology, immunohistochemistry, FISH, Western blot, PCR, and EMSA (Electrophoretic Mobility Shift Assay).
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Han X, Garcia-Manero G, McDonnell TJ, Lozano G, Medeiros LJ, Xiao L, Rosner G, Nguyen M, Fernandez M, Valentin-Vega YA, Barboza J, Jones DM, Rassidakis GZ, Kantarjian HM, Bueso-Ramos CE (2006) HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target. Mod Pathol. Nov 24; (in press)

Zhao W, Claxton DF, Jeffrey Medeiros L, Lu D, Vadhan-Raj S, Kantarjian HM, Nguyen MH, Bueso-Ramos CE (2006) Immunohistochemical analysis of CBFbeta-SMMHC protein reveals a unique nuclear localization in acute myeloid leukemia with inv(16)(p13q22). Am J Surg Pathol. Nov;30(11):1436-44.

Bueso-Ramos CE, Rocha FC, Shishodia S, Medeiros LJ, Kantarjian HM, Vadhan-Raj S, Estrov Z, Smith TL, Nguyen M, Aggarwal BB (2004) Expression of constitutively active nuclear-kB RelA transcription factor in blasts of acute myeloid leukemia. Hum Pathol 35:246-253.

Xiaoping S, Medeiros LJ, Lu D, Rassidakis GZ, Bueso-Ramos CE (2003) Dysplasia and high proliferation rate are common in acute myeloid leukemia with Inv(16)(p13q22). Am J Clin Pathol 120:1-10.

Mukhopadhyay A, Bueso-Ramos CE, Chatterjee D, Pantazis P, Aggarwal B (2001) Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20:7597.

Bannerjee S, Bueso-Ramos CE, Aggarwal BB (2002) Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 62(17):4945-4954.