Paul J. Chiao, Ph.D. 1990, The University of Texas at Houston Graduate School of Biomedical Sciences The University of Texas M. D. Anderson Cancer Center Department of Surgical Oncology Contact Information

Research Interests:

• The mechanism for cytokine-induced biphasic activation of Rel/NF-kappaB
• The signaling pathways for growth factor-induced Rel/NF-kappaB activation in cancers
• The mechanism by which Rel/NF-kappaB regulates both antiapoptotic and proapoptotic responses
• The role of NF-kB in the development of tumors and metastasis

The goal of my research is to understand the role of oncogenes and tumor suppressor genes in the development of tumors and metastasis. A tutorial in my laboratory would provide a learning experience in designing experiments and testing hypothesis using various techniques such as DNA and RNA isolation and purification, construction of expression vectors, transfection, inhibition of gene expression by small interfering RNA, kinase assay, electrophoretic mobility shift assay, reporter gene assays, Western, Southern, Northern blot analyses, PCR and protein purification.

Publications

Program Affiliation:

Program in Cancer Biology