William P. Dubinsky, Ph.D. 1976, St. Louis University The University of Texas Health Science Center at Houston Medical School Department of Integrative Biology and Pharmacology Contact Information Biographical Sketch

Research Interests:

• Membrane physiology
• Ion transport
• Reconstitution
• Regulation of ion fluxes
• Cystic fibrosis
• Epithelia

The long range objective of my research is to identify factors controlling membrane permeabilities at the molecular level. The model system currently under study is bovine tracheal epithelial Cl and Na transport. The approach involves detergent solubilization of purified membranes to extract transport complexes. These complexes are resolved into phospholipid vesicles. The studies are being extended to human tissues from normal and cystic fibrosis patients in an effort to identify the locus of the primary defect in this disease of electrolyte transport.

A tutorial in my laboratory would provide experience in membrane fractionation, ion transport studies, protein purification and resolution reconstitution.

Publications


Program Affiliation:

Program in Cell and Regulatory Biology (Physiology Track)