Madeleine Duvic, M.D. 1977, Duke University The University of Texas M.D. Anderson Cancer Center Department of Dermatology Contact Information Biographical Sketch

Research Interests:

• Translational research in the molecular pathogenesis and immunology of T cell mediated disorders (cutaneous lymphomas, psoriasis, alopecia areata) and skin cancers
• Clinical drug development for lymphoma, melanoma, and skin cancer involving retinoids, histone deacetylase inhibitors, targeted antibodies and fusion toxin

Objectives are [1] To understand the molecular mechanisms of cutaneous T-cell lymphomas (and other T-cell mediated diseases). [2] To develop FDA approved safe and effective therapies that modulate gene expression and induce T-cell apoptosis. [3] To elucidate the transforming activity of a lipid raft protein flotillin-2 and PAR-1 interactions in melanoma progression and as a target for effective therapy.

A tutorial in my laboratory would involve molecular biology techniques, tissue culture, gene modulation with siRNAs, immunology, immunohistochemistry, mouse tumor models, depending on the project selected.

Publications


Program Affiliations:

Program in Immunology

Program in Molecular Pathology