Robin Fuchs-Young, Ph.D.
1988, Vanderbilt University
UT M. D. Anderson Cancer Center
Science Park/Research Division
My laboratory is located in Smithville, Texas, at UT Science Park -- Research Division.
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Robin Fuchs-Young, Ph.D. 1988, Vanderbilt University UT M. D. Anderson Cancer Center My laboratory is located in Smithville, Texas, at UT Science Park -- Research Division. |
Research Interests: Breast development and tumorigenesis; uterine tumors; hormonal carcinogenesis; steroid hormone receptors; tissue-specific antiestrogens
The goal of my research is to improve our understanding of how steroid hormones affect development, growth and tumorigenesis and to identify pivotal molecular targets involved in these processes. This work utilizes in vitro and in vivo model systems to examine the tissue-specific activity of hormonal agents on the breast, uterus and other responsive organs. In addition to basic information on signal transduction pathways, this research will provide insight into the mechanism of action of endogenous and synthetic receptor ligands, including therapeutic candidates and environmental toxicants, at the cellular and molecular level.
A tutorial in my laboratory would provide experience with evaluations of mammary development and differentiation at the tissue, cellular and molecular level as well as the use of animal models to assess biological function. In addition, the student would be introduced to basic concepts in endocrinology and hormone action and gain experience with immunohistochemistry, western blotting, RNA and DNA extraction, traditional and quantitative PCR and confocal microscopy.
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Fuchs-Young R, Howe S, Hale L, Miles R, Walker C (1996) Inhibition of estrogen-stimulated growth of uterine leiomyomas by selective estrogen receptor modulators (SERMs). Molecular Carcinogenesis 17:151-159.
Hale LV, Layman N, Wilson P, Short L, Magee D, Wightman S, Fuchs-Young R (1997) Rapid tumor development using a modified MCF-7 xenograft model. Lab Animal Sci 47:82-85.
Burroughs KD, Kiguchi K, Howe SR, Fuchs-Young R, Trono D, Barrett JC, Walker C (1997) Regulation of apoptosis in uterine leiomyomata. Endocrinology 138:3056-3061.
Porter KB, Tsibris JCM, Porter GW, Fuchs-Young R, Nicosia SV, O'Brien WF, Spellacy WN (1998) Effects of Raloxifene in a guinea pig model for leiomyomata. Am J Obstet Gynecol 179:1283-1287.
Program Affiliations:
Program in Cell and Regulatory Biology Reproductive Biology Track
Program in Molecular
Carcinogenesis