Raymond J. Grill, Ph.D.
1995, University of Cincinnati
UT-Houston Medical School
Neurosurgery
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Raymond J. Grill, Ph.D. 1995, University of Cincinnati UT-Houston Medical School |
Research Interests: Spinal cord injury; trauma; vascular repair; inflammation; axonal regeneration; extracellular matrix; growth factors; gene therapy; functional recovery
The focus of my research is towards the generation of a multi-level approach in the treatment of the acute and chronic phases of spinal cord injury. This involves minimizing functional loss in the acute phase of injury by decreasing inflammation and repairing the devastated vascular network. In the chronic phase, attention is focused on stimulating axonal regeneration through the appliction of target-derived growth factors and the manipulation of the spinal extracellular matrix to provide a supportive growth terrain.
A student's tutorial experience in my lab could consist of several options, including training in small animal surgical techniques, blood-spinal cord barrier integrity studies, cellular transplantation utilizing a variety of cellular candidates, in vivo axonal growth assays, immunohistochemical and image analysis techniques and behavioral analyses
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Tuszynski MH, Grill R, Jones LL, Brant A, Blesch A, Low K, Lacroix S, Lu P (2003) NT3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection. Experimental Neurology 181:47-56.
Grill RJ (2003) Assessment of vascular integrity by endothelial barrier antigen immunoreactivity in both the acute and chronic phase of traumatic brain injury. (in preparation)
Grill RJ (2003) Hyper-acute and chronic cellular distribution of the NG2 proteoglycan following spinal contusion injury in the adult rat. (in preparation)
Grill RJ (2003) Microglial and vascular expression of brain-derived neurotrophic-factor following traumatic injury to the adult rat brain. (in preparation)
Program Affiliation:
Program in Neuroscience