Patrick Hwu, M.D. 1987, Medical College of Pennsylvania The University of Texas M. D. Anderson Cancer Center Department of Melanoma Medical Oncology Contact Information

Research Interests:

• Cancer immunology
• Cancer vaccines
• Tumor immunotherapy

Significant advances in our understanding of the immune response against cancer have allowed us to design rational immune therapies for patients. My laboratory is focused on the translation of basic immunologic concepts from the laboratory to the clinic. We have found that some patients with metastatic cancer can be successfully treated with infusions of tumor-reactive T-cells. We are currently investigating methods to improve these therapies, by studying T-cell proliferation, survival, and trafficking using murine models as well as human T-cells.

A tutorial in my lab would give students experience in:

• The basic concepts of cancer immunology
• Growth and characterization of tumor-reactive T-cells
• Murine models of tumor immunotherapy
• Measurement of cytokine levels by ELISA
• FACS analysis of tumor-reactive T-cells
• Measurement of immune responses following cancer vaccines

Publications

Program Affiliation:

Program in Immunology