Rosemary Kozar, M.D., Ph.D.
1986, Temple University School of Medicine
1992, Baylor College of Medicine
UT-Houston Medical School
Surgery
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Rosemary Kozar, M.D., Ph.D. 1986, Temple University School of Medicine UT-Houston Medical School |
Research Interests: The role of the gut in multiple organ failure; gut hypoperfusion
The research in my laboratory focuses on the role of the gut in multiple organ failure and is directed at understanding gut dysfunction following gut hypoperfusion. Current studies focus on the mechanisms by which enteral nutrients differentially contribute to gut dysfunction during times of metabolic stress.
Depending on the interest of the student, a tutorial inmy laboratory would provide experience ranging from animal surgery, energy metabolism, to assessment of gastrointestinal function (absorption, permeability, blood flow). Opportunities also exist in the clinical arena in which laboratory findings are applied to the care of patients. Clinical studies examining gut dysfunction following enteral administration of nutrients in critically injured patients are in progress.
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Kozar RA, Schultz SG, Weisbrodt N, DeSoignie R, Hassoun HT, Moore FA (2001) Specific enteral nutrients modulate gut ischemia/reperfusion injury in rats. Gastroenterology (submitted)
Kozar RA, Sen H, Hassoun HT, DeSoignie R, Moore FA (2001) Specific enteral nutrients alter mucosal blood flow during gut ischemia/reperfusion. JPEN (in press)
Moore FA, Cocanour CS, McKinley B, Kozar RA, DeSoignie R, VonMaszewski M, Weisbrodt N (2001) MMC's exist after trauma and predict enteral tolerance. J Trauma (in press)
Hassoun HT, Weisbrodt NW, Kozar RA, Mercer DW, Moody FG, Moore FA (2001) Inducible nitric oxide synthase mediates impaired small intestinal transit after severe gut ischemia/reperfusion. J Surg Res 97:150-156.
Kozar RA, Schultz SG, Hassoun HT, DeSoignie R, Moore FA (2001) Intraluminal nutrients alter gut permeability following gut ischemia/reperfusion. Shock 15 (Suppl 65).
Kozar RA, Schultz SG, Weisbrodt N, DeSoignie R, Hassoun MT, Moore FA (2000) Intraluminal nutrients enhance gut ischemia/reperfusion injury. Shock 13 (Suppl 28).