Yahuan Lou, Ph.D.
1990, Hokkaido University, Japan
The University of Texas Health Science Center at Houston
Dental Branch
Department of Diagnostic Science
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Yahuan Lou, Ph.D. 1990, Hokkaido University, Japan The University of Texas Health Science Center at Houston |
Research Interests:
The research in my laboratory is directed at understanding cellular and molecular mechanisms that initiate human autoimmune diseases using animal models. Presently, our studies focus on three areas of investigation: 1) elucidating peripheral tolerance mechanism, which is mediated by a specialized type of dendritic cells; 2) mapping gene or genes that are involved in the maintenance of peripheral tolerance; 3) investigating the role of interactions between immune cells and the ovarian environment in ovarian function.
A tutorial in my laboratory will provide an emphasis on immunology and autoimmune diseases. Students will have a hands-on experience with modern techniques such as cell culture, flow cytometry, basic cloning methods, microarray, mouse handling and the production of a transgenic mouse.
Selected Publications:
Arends J, J Wu, J Borillo, L Truong, C Zhou, N Vigneswaran, Y-H Lou (2006) T cell epitope mimicry in anti-glomerular basement membrane disease. J. Immunol. 176 (2): 1252-1258.
Wu J, J Arends, J Borillo, C Zhou, J Merszei, J McMahon, Y-H Lou (2004) A self T cell epitope induces autoantibody response: mechanism for production of antibodies to diverse glomerular basement membrane antigens. J. Immunol. 172(4):4567-4574.
Wu J, J Hicks, J Borillo, WF Glass II, Y-H Lou (2002) CD4 + T cells specific to glomerular basement membrane antigen induce glomerulonephritis. J. Clin. Invest. 109(4)517-524.
Program Affiliation:
Program
in Immunology