Michael C. MacLeod, Ph.D.
1974, University of Oregon
UT M. D. Anderson Cancer Center
Science Park/Research Division
My laboratory is located in Smithville, Texas, at UT Science Park -- Research Division.
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Michael C. MacLeod, Ph.D. 1974, University of Oregon UT M. D. Anderson Cancer Center My laboratory is located in Smithville, Texas, at UT Science Park -- Research Division. |
Research Interests: chemical carcinogenesis, breast cancer, DNA damage responses, mustard gas
We have recently discovered that the ATF3 gene, coding for a member of the bZip transcription factor family, acts as an oncogene in transgenic mice, producing tumors of the oral epithelium and of the mammary gland. Current work in the lab focuses on the mechanism of ATF3 action in these transgenic mice, particularly on possible effects on the Wnt/beta-catenin signaling pathway. In an unrelated project, we are involved in an NIH sponsored counter-terrorism consortium developing treatments for chemical threat agents that might be empoloyed by terrorists in this country. A previously developed cancer chemopreventive agent, 2,6-dithiopurine, is being studied as an effective scavenging agent against sulfur mustard gas, which is itself a powerful toxicant as well as a carcinogen.
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Wang A, Gu J, Judson-Kremer K, Powell KL, Mistry H, Simhambhatla P, Aldaz CM, Gaddis S, MacLeod MC (2003) Response of human mammary epithelial cells to DNA damage induced by BPDE: involvement of novel regulatory pathways. Carcinogenesis 24: 225-234.
Thavathiru E, Ludes-Meyers JH, MacLeod MC, Aldaz CM (2005) Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR. Mol Carcinog. 44:174-182.
Spyres L, Gaddis S, Bedford E, High S, Liburd N, Powell KL, Thames H, Mitchell D, Walborg E, Rouabhiad M, Aldaz CM, MacLeod MC (2005) Quantitative, high throughput measurement of gene expression with sub-zmol sensitivity by capillary electrophoresis. Analytical Biochem. 345: 284-295.
Wu Q, Gaddis SS, MacLeod MC, Walborg EF, Thames HD, DiGiovanni J, Vasquez KM (2006) High affinity triplex-forming oligonucleotide target sequences in mammalian genomes. Mol Carcinogenesis 46: 15-23.
Wang A, Arantes S, Conti C, McArthur M, Aldaz CM, MacLeod M (2007) Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells. Mol Carcinogenesis 46: 476-487.
Program Affiliations:
Program in Molecular
Carcinogenesis