Hope Northrup, M.D. 1983, Medical University of South Carolina The University of Texas Health Science Center at Houston Medical School Department of Pediatrics Contact Information Biographical Sketch

Research Interests:

• Medical genetics
• Molecular genetics of human disease
• Tuberous sclerosis
• Spina bifida

Research in my laboratory focuses on two disorders: tuberous sclerosis complex (TSC) and spina bifida cystica. TSC is inherited in an autosomal dominant fashion with two known genes on chromosome 9q34.3 (TSC1) and on chromosome 16p13.3 (TSC2) for the TSC phenotype. Current work underway includes mutational analysis and functional studies of both genes. The spina bifida project is using a candidate gene approach to search for genetic associations.

A tutorial in my laboratory will expose the student to common molecular genetic techniques including subcloning, DNA sequencing, Southern blot analysis, single strand conformational polymorphic analysis, cell free transcription-translation, protein-protein interaction techniques, Western blotting and immunoprecipitation.

Publications

Program Affiliations:

Program in Genetic Counseling

Program in Human and Molecular Genetics