Prahlad T. Ram, Ph.D.
1997, Tulane University
The University of Texas M. D. Anderson Cancer Center
Department of Systems Biology
|
Prahlad T. Ram, Ph.D. 1997, Tulane University The University of Texas M. D. Anderson Cancer Center |
Research Interests:
The research in my laboratory is focused on understanding signaling networks within cells and how these signaling events modulate gene expression and proliferation. Extracellular signals are routed through signaling networks where they can activate multiple pathways, integrate at different levels, and form positive and negative feedback loops. The laboratory uses a combination of computational modeling and experimental biology to gain a systems understanding of the network and how it regulates gene expression and proliferation.
Tutorials in my laboratory can include a wide range of topics
from computational modeling to biochemical analysis of signaling events to proteomics
using reverse phase high density lysate microarrays.
Selected Publications:
Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R (2005) Formation of regulatory patterns during signal propagation in a Mammalian cellular network Science 309:1078-83.
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB (2005) Exploiting the PI3K-AKT pathway for cancer drug discovery. Nature Review Drug Discovery 4:988-1004.
Ruths D, Muller M, Tseng J-T, Nakhleh L, Ram PT (2008) The signaling Petri Net-based simulator: A non-parametric strategy for characterizing the dynamics of cell-specific signaling networks PLoS Comp Biol Feb 29;4(2):e1000005.
Muller M, Obeyesekere M, Mills GM, Ram PT (2008) Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bi-fan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R. FASEB J 22:1393-403.