Harel Z. Shouval, Ph.D.
1994, Brown University
UT-Houston Medical School
Neurobiology and Anatomy
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Harel Z. Shouval, Ph.D. 1994, Brown University UT-Houston Medical School |
Research Interests: Theoretical studies of molecular, cellular, and system level substrates of learning, memory and development
At my lab we are interested in forming an integrated picture of learning, memory and development, processes that share many common mechanisms. We do this by developing mathematical models of the substrates of these processes, and studying these models using both computer simulations and analytical techniques. Since we strive to develop an integrated theory that can account for these processes, our studies span many levels of description from the molecular basis of synaptic plasticity to the system level properties of the visual cortex. The research in my lab is always closely related to experimental studies, and I have often closely collaborated with experimental labs.
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Rittenhouse CD et al (1999) Monocular deprivation induces homosynaptic long-term depression in visual cortex. Nature 397(6717):347-350.
Blais B, Cooper LN, Shouval H (2000) Formation of direction selectivity in natural scene environments. Neural Comput 12(5):1057-1066.
Shouval hZ et al (2000) Structured long-range connections can provide a scaffold for orientation maps. J Neurosci 20(3):1119-1128.
Castellani GC et al (2001) A biophysical model of bidirectional synaptic plasticity: dependence on AMPA and NMDA receptors. Proc Natl Acad Sci USA 98(22):12772-12777.
Shouval HZ et al (2002) Converging evidence for a simplified biophysical model of synaptic plasticity. Biol Cybern 87(5-6):383-391.
Shouval HZ, Bear MF, Cooper LN (2002) A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. Proc Natl Acad Sci USA 99(16):10831-10836.
Program Affiliation:
Program in Neuroscience