Louise C. Strong, M.D.

1970, University of Texas Medical Branch

UT M. D. Anderson Cancer Center
Cancer Genetics

Research Interests: Human cancer genetics; genetic epidemiology

The program involves the study of genetic etiology of human cancer using genetic epidemiologic approach to identify the most likely etiologic model(s) to account for the distribution of tumors in kindreds, and to test for genetic/etiologic heterogeneity. We then identify families in which a genetic etiology seems likely for collaborative study using cytogenetic, biochemical, and molecular markers to localize the gene. We are further investigating the role of radiation, chemotherapy, and host predisposing factors in the risk of subsequent tumors in childhood cancer survivors and in the reproductive outcomes in childhood cancer survivors.

A tutorial in this laboratory would include introduction to field work of data collection by interview, analytic techniques of genetic epidemiology, and interpretation of laboratory findings from the collaborative laboratory studies.

____________

Lustbader ED, Williams WR, Strom SS, Bondy ML, Strong LC (1992) Segregation analysis of cancer in families of childhood soft tissue sarcoma patients. Am J Hum Genet 51:344-356.

Strong LC, Williams WR, Tainsky MA (1992) The Li-Fraumeni syndrome: From clinical epidemiology to molecular genetics. Am J Epidemiol 135:190-199.

Strong LC, Amos C (1996) Inherited susceptibility. In: Cancer Epidemiology and Prevention, 1997, 2nd ed (JF Fraumeni, D Schottenfeld, eds). New York: Oxford University Press.

Program Affiliation:
Program in Human and Molecular Genetics
Program in Genetic Counseling