Heinrich Taegtmeyer, M.D., D.Phil.
1968, University of Freiburg; 1981, University of Oxford
UT-Houston Medical School
Cardiology
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Heinrich Taegtmeyer, M.D., D.Phil. 1968, University of Freiburg; 1981, University of Oxford UT-Houston Medical School |
Research Interests: energy substrate metabolism; gene expression and function of the heart; heart failure and diabetes
We examine the dynamics of energy transfer and of alterations in work load on gene expression of the heart. At the molecular level, we study mechanisms by which metabolically generated signals regulate signaling pathways of cardiac protein turnover, including the induction of cardiac specific genes. To accomplish this goal, we make use of a variety of models, including the hypertrophied and atrophied heart in vivo, isolated working hearts, and isolated heart muscle cells in culture. At the clinical level we study molecular mechanisms of heart failure and the effects of diabetes and obesity on the heart. Here we make use of an extensive clinical data base and heart muscle samples generated in the course of implantation of left ventricular assist devices and at transplantation of failing human hearts. In separate studies we examine the cardiovascular consequences of severe obesity in patients and in rodent models.
A tutorial in my laboratory includes an introduction to a variety of techniques, including small animal surgery, breeding of genetically engineered animals, perfusion techniques of the heart, isolation of neonatal and adult cardiac myocytes, tracer methods to study metabolic fluxes, measurements of metabolites, hormones and enzyme activities, as well as an assessment of metabolic activities, quantitative RT-PCR, immunoblotting, immunoprecipitation, and electrophoretic mobility shift assays. There are weekly lab seminars and lab meetings.
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Wilson CR, Tran MK, Salazar KL, Young ME, Taegtmeyer H. Western diet causes derangements
of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats. Biochem J. 2007; 406:457-67 .
Sharma S, Guthrie P, Chan S, Haq S, Taegtmeyer H. Glucose phosphorylation is required for insulin-dependent mTOR signaling in the heart. Cardiovasc Res2007; 76:71-80.
Razeghi P, Baskin KK, Sharma S, Young ME, Stepkowski S, Essop M, Taegtmeyer H (2006) Atrophy, hypertrophy and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart. Biochem Biophys Res Commun. 342:361-364.
Sharma S, Dewald O, Adrogue J, Razeghi P, Salazar RL, Crapo JD, Bowler RP, Entman ML, Taegtmeyer H (2006) Induction of antioxidant gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species. Free Radic Biol Med. 40:2223-2231.
Leichman JG, Aguilar D, King TM, Vlada A, Reyes M, Taegtmeyer H (2006) An association of plasma free fatty acids and left ventricular diastolic function in patients with clinically severe obesity. Am J Clin Nutr. 84:336-341.
Razeghi P, Volpini KC, Wang M-E, Youker KA, Stepkowski S, Polonsky KS, Taegtmeyer H (2006) Mechanical unloading of the heart activates the calpain system. J Mol Cell Cardiol. 2007; 42:449-452.
Leichman J , Aguilar D, Mehta S, Scarborough T, Wilson EB, Taegtmeyer H (2006)Improvements in systemic metabolism, anthropometrics, and left ventricular geometry three months after bariatric surgery. Surg Obesity Rel Dis. 2:592-599.
Razeghi P, Buksinska-Lisik M, Palanichamy N, Stepkowski S, Frazier OH, Taegtmeyer H. (2006) Transcriptional regulators of ribosomal biogenesis are increased in the unloaded heart. FASEB J 20:1090-1096.
Dewald O, Sharma S, Adrogue J, Salazar R, Duerr GD, Crapo JD, Entman ML, Taegtmeyer H. (2005) Dowregulation of PPARα-activated receptor-α gene expression in a mouse model of ischemic cadiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation 112:407-15.
Golfman LS, Wilson CR, Sharma B, Burgmaier M, Young, Guthrie PH, Van Arsdall M, Adrogue JV, Brown KK, Taegtmeyer H (2005) Activation of PPAR{gamma} enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats. Am J Physiol Endocrinol Metab 289:E328-36.
Skurk C, Izumiya Y, Maatz H, Razeghi P, Shiojima I, Sandri M, Sato K, Zeng L, Schiekofer S, Pimentel D, Lecker S, Taegtmeyer H, Goldberg AF, Walsh K (2005) The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem 280:20814-20823.
Sharma S, Adrogue JV, Golfman L, Uray I, Lemm J, Youker K, Noon GP, Frazier OH, Taegtmeyer H (2004) Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.
FASEB J. Nov 18 (14):1692-700.
Taegtmeyer H (2004) Cardiac metabolism as a target for the treatment of heart failure. Circulation 110(8):894-6.
Taegtmeyer H (2004) Glycogen in the heart--an expanded view. J Mol Cell Cardiol 37(1):7-10.
Taegtmeyer H, Golfman L, Sharma S, Razeghi P, van Arsdall M (2004) Linking gene expression to function: metabolic flexibility in the normal and diseased heart. Ann N Y Acad Sci 1015:202-13.
Weisleder N, Soumaka E, Abbasi S, Taegtmeyre H, Capetanaki Y (2004) Cardiomyocyte-specific desmin rescue of desmin null cardiomyopathy excludes vascular involvement. J Mol Cell Cardiol 36(1):121-8.
Sharma S, Taegtmeyer H, Adrogue J, Razeghi P, Sen S, Ngumbela K, Essop ME (2004) Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy. Am J Physiol Heart Circ Physiol 286(3):H1185-92.
Razeghi P, Sharma S, Ying J, Li YP, Stepkowski S, Reid MB, Taegtmeyer H (2003) Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradation. Circulation 108(20):2536-41.
Castro-Chavez F, Yechoor VK, Saha PK, Martinez-Botas J, Wooten EC, Sharma S, O’Connell P, Taegtmeyer H, Chan L (2003) Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes 52(11):2666-74.
Haffner S, Taegtmeyer H (2003) Epidemic obesity and the metabolic syndrome. Circulation 108(13):1541-5.
Razeghi P, Bruckner BA, Shamra S, Youker KA, Frazier OH, Taegtmeyer H (2003) Mechanical unloading of the failing human heart fails to activate the protein kinase B/Akt/glycogen synthase kinase-3beta survival pathway. Cardiology 100(1):17-22.
Cohen DM, Guthrie PH, Gao X, Sakai R, Taegtmeyer H (2003) Glutamine cycling in isolated working rat heart. Am J Physiol Endocrinol Metab 285(6):E1312-6.
Uray IP, Connelly JH, Frazier OH, Taegtmeyer H, Davies PJ (2003) Mechanical unloading increases caveolin expression in the failing human heart. Cardiovasc Res 59(1):57-66.
Razeghi P, Essop MF, Huss JM, Abbasi S, Manga N, Taegtmeyer H (2003) Hypoxia-induced switches of myosin heavy chain iso-gene expression in rat heart. Biochem Biophys Res Commun 303(4):1024-7.
Xia Y, Wen HY, Young ME, Guthrie PH, Taegtmeyer H, Kellems RE (2003) Mammalian target of rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine. J Biol Chem 278(15):13143-50.
Taegtmeyer H (2002) Switching metabolic genes to build a better heart. Circulation 106(16):2043-5.
Young ME, Guthrie PH, Razeghi P, Leighton B, Abbasi S, Patil S, Youker KA, Taegtmeyer H (2002) Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart. Diabetes 51(8):2587-95.
Razeghi P, Young ME, Cockrill TC, Frazier OH, Taegtmeyer H (2002) Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure. Circulation 106(4):407-11.
Taegtmeyer H, McNulty P, Young ME (2002) Adaptation and maladaptation of the heart in diabetes: Part I: general concepts. Circulation 105(14):1727-33.
Young ME, McNulty P, Taegtmeyer H (2002) Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms. Circulation 105(15):1861-70.
Belke DD, Betuing S, Tuttle MJ, Graveleau C, Young ME, Pham M, Zhang D, Cooksey RC, McClain DA, Litwin Se, Taegtmeyer H, Severson D, Kahn CR, Abel ED (2002) Insulin signaling coodinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 109(5):629-39.
Razeghi P, Mukhopadhyay M, Myers TJ, Moravec CS, Frazier OH, Taegtmeyer H (2001) Myocardial tumor necrosis factor-alpha expression does not correlate with clinical indices of heart failure in patients on left ventricular assist device support. Ann Thorac Surg 72(6):2044-50.
Razeghi P, Young ME, Alcorn JL, Moravec CS, Frazier OH, Taegtmeyer H (2001) Metabolic gene expression in fetal and failing human heart. Circulation 104(24): 2923-31.
Young ME, Laws FA, Goodwin GW, Taegtmeyer H (2001) Reactivation of peroxisome proliferator-activated receptor alpha is associated with contractile dysfunction in hypertrophied rat heart. J Biol Chem 276(48):44390-5.
Razeghi P, Young ME, Abbasi S, Taegtmeyer H (2001) Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated gene expression in rat heart. Biochem Biophys Res Commun 287(1):5-10.
Young ME, Patil S, Ying J, Ahuja HS, Shipley GL, Stepkowski SM, Davies PJ, Taegtmeyer H (2001) Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart. FASEB J 15(3):833-45.
Goodwin GW, Cohen DM, Taegtmeyer H (2001) [5-3H]glucose overestimates glycolytic flux in isolated working rat heart: role of the pentose phosphate pathway. Am J Physiol Endocrinol Metab 280(3):E502-8.
Young ME, Goodwin GW, Ying J, Guthrie P, Wilson CR, Laws FA, Taegtmeyer H (2001) Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. Am J Physiol Endocrinol Metab 280(3):471-9.
Depre C, Shipley GL, Chen W, Han Q, Doenst T, Moore ML, Stepkowski S, Davies PJ, Taegtmeyer H (1998) Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nature Med 4(11):1269-75.
Goodwin GW, Taylor CS, Taegtmeyer H (1998) Regulation of energy metabolism in the heart during acute increase in heart work. J Biol Chem 273(45):29530-9.
Program Affiliations:
Program in Cell and Regulatory
Biology (Physiology Track)
Program in Molecular Pathology
Vascular Biology