Eric J. Wagner, Ph.D. 2002, Duke University The University of Texas Health Science Center at Houston Medical School Department of Biochemistry and Molecular Biology Contact Information Biographical Sketch

Research Interests:

• Cell cycle regulation of RNA processing, specifically of histone mRNA
• Biosynthesis of small nuclear RNA including the U1, U4, and U7 snRNAs
• Developmental regulation of Drosophila histone mRNA and snRNA

The research in my laboratory applies a systems biology approach of high throughput analysis using genome-wide RNA interference screening technology.  We use this approach to identify novel genes involved in the regulation of histone mRNA during S phase as well as genes governing the synthesis of snRNA. 

A research tutorial in my lab will allow a student to use a combination of biochemical, molecular biological, and genetic approaches in both human cells and Drosophila.


Selected Publications:

Wagner EJ, Burch BD, Godfrey A, Salzler HR, Duronio RJ, Marzluff WF (2007) A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing. Mol Cell.  Nov 30;28(4):692-9.

Marzluff WF, Wagner EJ, Duronio RJ (2008)  Histone mRNA metabolism: Life without a polyA Tail.  Invited review at Nature Reviews Genetics. Nov;9(11):843-54.  

Wagner EJ, Marzluff (2006) ZFP100 is a Limiting Component of the U7snRNP that is required for G1/S phase Transition. Mol Cell Biol. Sep;26(17):6702-12.

Additional Publications

Program Affiliation:

Program in Biochemistry and Molecular Biology