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Huamin Wang, M.D., Ph.D. 1987, Tongji Medical University UT M. D. Anderson Cancer Center |
Research Interests: signal transduction; tumor markers; molecular genetics and genomics of pancreatic cancer; therapeutic targets
Pancreatic cancer is the fourth leading cause of cancer death for both men and women in the US. The molecular mechanisms leading to pancreatic cancer have not been elucidated. The goal of my research is to understand the role of oncogenes, tumor suppressor genes in the development of pancreatic cancer, and develop therapeutic targets for cancer treatments that are based on novel mechanisms of action. We are particularly interested in protein kinases and phosphotases that have been implicated in pancreatic cancer. Current research in my laboratory is directed to understand the function of the MAP4K family of mammalian Ste20-related protein kinases and their phosphotases in pancreatic cancer.
Depending on the student’s interests, a tutorial in my laboratory would provide experience with cell culture, animal models and surgical specimens from human pancreatic cancer. The student would learn basic molecular biology methods, participate in translational studies using antibody array, tissue microarray, siRNA, in vivo tumor models and gene delivery technology.
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Wang H, Wang H, Zhang W, Huang H, Liao W, Fuller GN (2004) Analysis of the activation status of Akt, NF k B and Stat3 in human diffuse gliomas, Laboratory Investigation, 84(8): 941-51.
Wang H, Rosen D, Wang H, Fuller GN, Zhang W, Liu J (2006) Insulin-like growth factor binding protein 2 and 5 are differentially regulated in ovarian cancer of different histologic types, Mod Pathol, 19:1149-56.
Mann AP, Verma A, Sethi G, Manavathi B, Wang H, Fok JY, Kumar R, Aggarwal BB, Mehta K (2006) Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor k B in cancer cells: Delineation of a novel pathway, Cancer Res, 66(17): 8788-95.
Verma A, Wang H, Fok J Y, Mann A P, Manavathi B, Kumar R, Mehta K (2006) Increased Expression of Tissue Transglutaminase in Pancreatic Ductal Adenocarcinoma and Its Implications in Drug Resistance and Metastasis, Cancer Res, 66(21): 10525-33.