Stephanie S. Watowich, Ph.D.
1990, Northwestern University
The University of Texas M. D. Anderson Cancer Center
Department of Immunology
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Stephanie S. Watowich, Ph.D. 1990, Northwestern University The University of Texas M. D. Anderson Cancer Center |
Research Interests:
The goal of my research is to understand the molecular mechanisms that control the development and function of immune cells, with particular emphasis on the role that cytokines play in immunity. We use in vivo model systems to examine the biological function of cytokine signaling intermediates in the STAT transcription factor family within the immune system. A tutorial in my laboratory will provide experience in current immunological and molecular biology techniques. More importantly, the tutorial will focus on learning to think independently and to choose exciting, and medically relevant research projects.
Selected Publications:
Panopoulos, A., Zhang, L., Snow, J., Jones, D., Smith, A., El Kasmi, K., Liu, F., Goldsmith, M., Link, D., Murray, P. Watowich, S. (2006) STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood 108:3682-3690.
Nurieva, R., Yang, X., Panopoulos, A., Martinez, G., Zhang, Y., Ma, L., Schluns, K., Tian, Q., Watowich, S., Jetten, A., Dong, C. (2007) Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448:480-483.
Esashi, E., Wang, Y.-H., Perng, O., Qin, X.-F., Liu, Y.-J., Watowich, S. (2008) GM-CSF and STAT5 directly inhibit IRF8 expression and block plasmacytoid dendritic cell development. Immunity, 28:509-520.
Panopoulos, A. Watowich, S. (2008) Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and ‘emergency’ hematopoiesis. Cytokine 42:277-88.
Program Affiliation: