Edward T.H. Yeh, M.D.
1980, University of California, Davis
The University of Texas M. D. Anderson Cancer Center
Department of Cardiology
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Edward T.H. Yeh, M.D. 1980, University of California, Davis The University of Texas M. D. Anderson Cancer Center |
Research Interests:
Ubiquitination plays a central role in the biology of cells. Our laboratory has discovered two families of ubiquitin-like proteins (SUMO/Sentrin and NEDD8), which defined novel protein modification pathways distinct from ubiquitination. These new pathways also play critical roles in cell cycle progression, signal transduction, and in cell death protection. Our laboratory has a comprehensive program in defining the biology of these pathways and in applying this basic knowledge to clinically relevant disease processes. In addition, my laboratory pioneered in using peripheral blood stem cells to regenerate damaged heart tissues. We have developed in vivo and in vitro models to investigate the mechanism of cell fusion that leads to the regeneration of cardiomyocytes. A student may choose between these two broad areas of innovative research.
Selected Publications:
Gao, F., Cheng, J., Shi, T., Yeh, E.T.H. (2006) NEDDylation of a Breast Cancer-associated Protein Recruits a Class III Histone Deacetylase that Represses NF k B-dependent Transcription. Nature Cell Biology, 8(10):1171-1177.
Zhang, S., Shpall, E., Willerson, J.T. Yeh, E.T.H. (2007) Fusion of Human Hematopoietic Progenitor Cells and Murine Cardiomyocytes is Mediated by α4β1/VCAM-1 Interaction. Circulation Research, 100:693-702.
Cheng, J., Kang, X., Zhang, S., Yeh, E.T.H. (2007) SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia. Cell, 131:584-595.
Bawa-Khalfe, T., Cheng, J., Wang, Z., Yeh, E.T.H. (2007) Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells. Journal of Biological Chemistry, 282(52):37341-37349.
Program Affiliations:
Program in Molecular Pathology
Vascular Biology