M. James You, M.D., Ph.D.

1986, Zhejiang University School of Medicine
1997, The University of Texas at Austin

The University of Texas M. D. Anderson Cancer Center
Department of Hematopathology

Contact Information

Research Interests:

Our laboratory is interested in cancer biology and genetics as well as translational research. Our current focus is myeloid and lymphoid neoplasm using genetic and oncogenomic approaches to uncover important genetic events that may drive tumor initiation and progression. Approaches include Cre / Lox- and Flp / FRT-based conditional systems to generate genetically engineered mouse models, including acute leukemia, which permits studies of the underlying biology and mechanisms of various tumor types. In addition, we complement basic mechanistic studies with translational research on human tumor specimens, which helps to correlate genetic changes, expression profiling, or other molecular signatures with clinical behavior and outcome.

Depending on student interests, a tutorial in my laboratory would provide students with exposure to techniques to analyze cancer phenotypes, molecular biology, cell biology, and translation research techniques.


Selected Publications